Danger Abounds When Meds and Your Genes Don’t Mix
https://ift.tt/2GPUDBl Karen Daggett, Frazee, MN. Mary Relling, PharmD, chair, pharmaceutical sciences, St. Jude Children’s Research Hospital; team leader, Clinical Pharmacogenetics Implementation Consortium. Jennifer Hockings, PhD, PharmD, pharmacogenomics clinical specialist, Genomic Medicine Institute, Cleveland Clinic. Tracy Glauser, MD, co-director, Genetic Pharmacology Service, Cincinnati Children’s Hospital. The Journal of Molecular Diagnostics: “Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade.” FDA.gov: “Table of pharmacogenomics biomarkers in drug labeling.” Office of Disease Prevention and Health Promotion: “Adverse drug events.” Stanford University: “Understanding genetics.” University of Utah: “Observable human characteristics.” National Library of Medicine, Genetics Home Reference. Medical Genetics Summaries: “Tamoxifen therapy and CYP2D6 genotype.” PharmGKB: “Very important pharmacogene: HLA-B.” Mayo Clinic: “Stevens-Johnson Syndrome.” F1000 Research: “Toxic epidermal necrolysis.” Frontiers in Genetics: “HLA-B allele and haplotype diversity among Thai patients identified by PCR-SSOP: evidence for high risk of drug-induced hypersensitivity.” Clinical Pharmacogenetics Implementation Consortium. Health via WebMD Health https://www.webmd.com/ February 28, 2019 at 11:22AM
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