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After studying their effects in mice, scientists at the University of Wisconsin-Madison conclude that branched-chain amino acids (BCAAs) are important for metabolic heath in obese animals. "We've identified an unanticipated role for dietary BCAAs in the regulation of energy balance," explains co-principal investigator Dudley Lamming, who works as an assistant professor in the Division of Endocrinology, Diabetes and Metabolism. In a study paper that was recently published in The Journal of Physiology, he and his team suggest that, if the findings translate to humans, then "specifically reducing dietary BCAAs" might be an effective way to treat obesity and insulin resistance. BCAAs' crucial role in vital body functionsBCAAs are a group of essential amino acids that includes leucine, isoleucine, and valine. Essential amino acids are those that the body needs to get from food sources, as it cannot make them to a level that is sufficient for healthy growth. Red meat and dairy products are rich dietary sources of BCAAs. People who follow vegan diets can also get them from vegetable sources such as soy protein. In the body, BCAAs are important for producing neurotransmitters, which are the chemical messengers of the brain and central nervous system. BCAAs are also important for making collagen, regulating insulin and glucose, and the healthy functioning of organs that help to maintain metabolism. 'Rapid reversal of diet-induced obesity'In their study, Prof. Lamming and his team put pre-diabetic, obese mice on a Western diet that was low in leucine, isoleucine, and valine but otherwise not restricted in amount of calories, fat, and sugar. The mice could eat as much of this low-BCAA food as they desired. During the study, the team monitored the animals' energy usage, glucose metabolism, and body weight and composition. The results showed that — despite being able to eat as much high-fat and high-sugar food as they wanted — the mice on the low-BCAA diet showed a dramatic improvement in metabolic health. The researchers note that reducing BCAAs in the diet "rapidly reverses diet-induced obesity" and improves glucose control in diet-induced obese mice. "Most dramatically," the study authors add, "mice eating an otherwise unhealthy high-calorie, high-sugar Western diet with reduced levels of BCAAs lost weight and fat mass rapidly until regaining a normal weight." Increased energy use, not increased activityThe team suggests that an important factor in the "normalization of weight" was that it came about not as a result of "caloric restriction or increased activity," but as a result of increased energy use that involved "the energy balance regulating hormone FG21." The weight loss witnessed was also "accompanied by a dramatic improvement in glucose tolerance and insulin resistance." The study confirms an increasing amount of evidence suggesting that protein metabolism is as important in insulin resistance as fat and carbohydrate metabolism. The study authors write that their findings "suggest that specifically reducing dietary BCAAs may represent a highly translatable option for the treatment of obesity and insulin resistance." However, previous evidence on the effect that BCAAs specifically have on insulin resistance is conflicting and has caused some experts to remark that "species difference" might be a factor. This would suggest, therefore, that the results of this study should be treated with caution until the question of "if the results translate to humans" is resolved.
Weight Loss via Obesity / Weight Loss / Fitness News From Medical News Today http://ift.tt/O45xlc December 21, 2017 at 10:20AM
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The Flat Belly FixThis is the only 21-day rapid weight loss system that allows you to easily lose an average of 1 lb a day for 21 days without feeling hungry or deprived. The unique and brand new techniques used in this System are proven SAFE. And they do not cause the rebound weight gain common to all the other rapid weight loss systems that are not backed by the latest science. The Flat Belly Fix System takes advantage of a recent scientific discovery that proves the effective weight loss power of an ancient spice. Combined with other cutting-edge ingredients in the patent-pending Flat Belly Fix Tea™ — that you can make right in your own kitchen in minutes — this System is the quickest, easiest and most enjoyable way to quickly get the body you desire and deserve. Click HereArchives
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