Type 2 diabetes, obesity may soon be reversed with gene therapy
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Small alterations to our genes could soon reverse metabolic disorders such as obesity and type 2 diabetes in humans.
The prevalence of diabetes, or the total number of existing cases, is on the rise in the United States and globally. According to recent estimates, over 30 million U.S. adults had diabetes in 2015. Although the number has been relatively steady in the past few years, rates of newly diagnosed cases among children and teenagers haveincreased sharply. And, worldwide, the situation is even more alarming; the number of people with diabetes almost quadrupled between 1980 and 2014, according to the World Health Organization (WHO). Now, new research brings much-needed hope of curing this metabolic disorder. Scientists led by Fatima Bosch, a professor at the Universitat Autònoma de Barcelona (UAB) in Catalunya, Spain, have successfully reversed the disorder in rodents. Prof. Bosch and her colleagues achieved this using gene therapy, a technique that introduces new genetic material into cells to create beneficial proteins or to offset the effects of malfunctioning genes. The findings were published in the journal EMBO Molecular Medicine. Using the FGF21 gene to reverse diabetesProf. Bosch and team designed two mouse models of obesity and type 2 diabetes. One was diet-induced, and the other one was genetically modified. Using an adeno-associated viral vector as "transport," the team delivered the fibroblast growth factor 21 (FGF21) gene. This gene is responsible for encoding the FGF21 protein, which is seen as a "major metabolic regulator" that stimulates the absorption of blood sugar in adipose tissue. By delivering this gene, the researchers stimulated the production of the protein, which caused the rodents to lose weight and lowered their insulin resistance — a major risk factor for type 2 diabetes. Additionally, the mice lost weight and the treatment reduced the fat and inflammation in their adipose tissue. The fat content, inflammation, and fibrosis of the rodents' livers were completely reversed, with no side effects. In turn, these improvements increased insulin sensitivity. These beneficial effects were noted in both murine models. Also, the team found that administering FGF21 to healthy mice prevented age-related weight gain and led to healthy aging. Gene therapy was used to alter three tissue types: liver tissue, adipose tissue, and skeletal muscle. "This gives a great flexibility to the therapy," explains Prof. Bosch, "since it allows [us] to select each time the most appropriate tissue, and in case some complication prevents manipulating any of the tissues, it can be applied to any of the others." "When a tissue produces FGF21 protein and secretes it into the bloodstream, it will be distributed throughout the body," adds Prof. Bosch. First reversion of obesity, insulin resistanceStudy co-author and UAB researcher Claudia Jambrina explains that their findings are particularly significant given that "the prevalence of type 2 diabetes and obesity is growing at alarming rates around the world." The team also says that delivering FGF21 as a conventional drug would not yield the same benefits as gene therapy; firstly, the drug would have to be administered periodically for long-term benefits, and secondly, its toxicity would be high. Using gene therapy, however, is free of side effects, and a single administration is enough to make the mice produce the protein naturally for several years.
"The results demonstrate that it is a safe and effective therapy," she adds. The next steps will be to "test this therapy in larger animals before moving to clinical trials with patients," notes Prof. Bosch. "[T]he therapy described in this study," she concludes, "constitutes the basis for the future clinical translation of FGF21 gene transfer to treat type 2 diabetes, obesity, and related comorbidities." Weight Loss via Obesity / Weight Loss / Fitness News From Medical News Today https://ift.tt/O45xlc July 12, 2018 at 03:54AM
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The Flat Belly FixThis is the only 21-day rapid weight loss system that allows you to easily lose an average of 1 lb a day for 21 days without feeling hungry or deprived. The unique and brand new techniques used in this System are proven SAFE. And they do not cause the rebound weight gain common to all the other rapid weight loss systems that are not backed by the latest science. The Flat Belly Fix System takes advantage of a recent scientific discovery that proves the effective weight loss power of an ancient spice. Combined with other cutting-edge ingredients in the patent-pending Flat Belly Fix Tea™ — that you can make right in your own kitchen in minutes — this System is the quickest, easiest and most enjoyable way to quickly get the body you desire and deserve. Click HereArchives
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