Weight loss drug may prevent and treat diabetes
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A new weight loss pill may prevent diabetes in those who are obese and overweight.
More than 30 million people, or 9 percent of the population of the United States, are living with diabetes, explain the Centers for Disease Control and Prevention (CDC). Overall, more than 100 million U.S. adults, or a third of the adult population, now have either diabetes or prediabetes, report the CDC. The current treatment options include oral drugs such as metformin, various forms of insulin, and interventions such as weight loss surgery. New research recently presented at the 2018 Meeting of the European Association for the Study of Diabetes, held in Berlin, Germany, makes a new addition to this treatment arsenal. The weight loss drug lorcaserin was shown to reduce the risk of diabetes complications, induce diabetes remission, and lower the risk of developing the condition in a clinical trial led by researchers from the Brigham and Women's Hospital (BWH) in Boston, MA. BWH scientists from the Thrombolysis in Myocardial Infarction (TIMI) Study Group conducted the trial, and the findings they presented were from the CAMELLIA-TIMI 61 clinical trial. Eisai Inc., the company that manufactures the drug, funded the trial. Dr. Erin Bohula, a BWH cardiovascular medicine specialist and a staff investigator for the TIMI Study Group, co-led the research together with Dr. Benjamin Scirica, also a cardiovascular medicine specialist at BWH and senior investigator for the TIMI Study Group. How lorcaserin affects diabetes, prediabetesThe CAMELLIA-TIMI 61 trial included 12,000 people who were either overweight or obese and were at risk of developing cardiovascular disease. Additionally, over half of the participants had diabetes and a third had prediabetes. Half of the participants were allocated to receive the weight loss drug, while the other half received placebo. The researchers monitored the participants for an average period of over 3 years. The trial revealed the following:
However, the study authors also report that lorcaserin significantly increased the number of severe cases of hypoglycemia among people who were already taking insulin or other treatments for diabetes known to raise the risk of hypoglycemia. "We recently presented findings showing that use of lorcaserin resulted in modest but sustained weight loss among obese and overweight patients without increasing risk of heart attack and stroke," explains Dr. Bohula. In this trial, the drug resulted in a weight loss of 4.2 kilograms, on average, compared with 1.4 kilograms in the placebo group.
Dr. Scirica also comments on the recent findings, saying, "Taken together, these findings reinforce the notion that modest, durable weight loss can improve cardiometabolic health and supports the role of lorcaserin as an adjunctive therapy in chronic weight management." "It provides another tool in the armamentarium, beyond diet and exercise, for patients hoping to achieve and maintain weight loss." "And, happily, as we saw, even relatively modest weight loss can improve the diabetes control in those with diabetes and reduce the development of diabetes in those at risk," Dr. Scirica says. "Given the global prevalence of obesity and its association with type 2 diabetes and complications that can cause death or greatly diminish quality of life, we need therapeutic strategies that can be added to lifestyle modification to prevent and control diabetes," he adds. "This rigorous and large-scale randomized study demonstrates the potential for improving glycemic control when adding a weight loss agent to a treatment plan." Weight Loss via Obesity / Weight Loss / Fitness News From Medical News Today https://ift.tt/O45xlc October 8, 2018 at 10:56AM
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The Flat Belly FixThis is the only 21-day rapid weight loss system that allows you to easily lose an average of 1 lb a day for 21 days without feeling hungry or deprived. The unique and brand new techniques used in this System are proven SAFE. And they do not cause the rebound weight gain common to all the other rapid weight loss systems that are not backed by the latest science. The Flat Belly Fix System takes advantage of a recent scientific discovery that proves the effective weight loss power of an ancient spice. Combined with other cutting-edge ingredients in the patent-pending Flat Belly Fix Tea™ — that you can make right in your own kitchen in minutes — this System is the quickest, easiest and most enjoyable way to quickly get the body you desire and deserve. Click HereArchives
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